Abstract Biosynthesis of zinc oxide nanoparticles (ZnO-NPs) was achieved by utilizing the reducing and capping potential of leaf, stem and callus aqueous extracts of Mussaenda frondosa. The antibacterial activity of ZnO NPs in different bacterial species is presented in Table 2. Instructions for using Copyright Clearance Center page for details. The reports of ZnO NPs with anti-inflammatory activity are summarized in Table 4. Biosynthetic and environment friendly technology for the synthesis of ZnO NPs are believed to be more ecofriendly, economical (low priced), nontoxic, and biocompatible than chemical and physical methods. Furthermore, it sheds light on the importance of zinc under physiological conditions. Sharma et al. Park, âFunctionalized ZnO nanoparticles with gallic acid for antioxidant and antibacterial activity against methicillin-resistant, T. Ohira and O. Yamamoto, âCorrelation between antibacterial activity and crystallite size on ceramics,â, S. Sarwar, A. Ali, M. Pal, and P. Chakrabarti, âZinc oxide nanoparticles provide anti-cholera activity by disrupting the interaction of cholera toxin with the human GM1 receptor,â, S. N. Seclen, M. E. Rosas, A. J. Arias, and C. A. Medina, âElevated incidence rates of diabetes in Peru: report from PERUDIAB, a national urban population-based longitudinal study,â, A. Nazarizadeh and S. Asri-Rezaie, âComparative study of antidiabetic activity and oxidative stress induced by zinc oxide nanoparticles and zinc sulfate in diabetic rats,â, R. D. Umrani and K. M. Paknikar, âZinc oxide nanoparticles show antidiabetic activity in streptozotocin-induced Type 1 and 2 diabetic rats,â, R. Malizia, A. Scorsone, P. DâAngelo, C. Lo Pinto, L. Pitrolo, and C. Giordano, âZinc deficiency and cell-mediated and humoral autoimmunity of insulin-dependent diabetes in thalassemic subjects,â, R. Kitture, K. Chordiya, S. Gaware et al., âZnO nanoparticles-red sandalwood conjugate: a promising anti-diabetic agent,â, J. Hussein, M. El-Banna, T. A. Razik, and M. E. El-Naggar, âBiocompatible zinc oxide nanocrystals stabilized via hydroxyethyl cellulose for mitigation of diabetic complications,â, A. Bayrami, S. Parvinroo, A. Habibi-Yangjeh, and S. Rahim Pouran, âBio-extract-mediated ZnO nanoparticles: microwave-assisted synthesis, characterization and antidiabetic activity evaluation,â, A. Amiri, R. A. F. Dehkordi, M. S. Heidarnejad, and M. J. Dehkordi, âEffect of the zinc oxide nanoparticles and thiamine for the management of diabetes in alloxan-induced mice: a stereological and biochemical study,â, N. S. Wahba, S. F. Shaban, A. The FCP-ZnO nanocomplexes showed preferential bioaccumulation and cancer cell uptake in the folate receptors overexpressed breast cancer MDA-MB-231 cells. ZnO nanostructures were successfully attached onto or penetrated into the cells, which suggested that ZnO nanosheets with visible yellow-orange emission could act as a feasible label for the bioimaging. These results demonstrated that ZnO NPs with a small size had great effects on reducing skin inflammation in AD models. ZnO NPs exposed remarkable anti-inflammatory activity by dose-dependently suppressing NO production as well as the related protein expressions of iNOS, COX-2, IL-1Î², IL-6, and TNF-Î±. ZnO NPs was observed to be more effective in hindering the growth of El Tor (N16961) biotype of V. cholera, which was closely associated with ROS production. Impaired autophagic flux resulted in the accumulation of damaged mitochondria, which could generate excessive ROS to cause cell death. Finally, the male ratsâ sexual behavior â¦ The activity of antibiotics against the tested dermatophytes was enhanced, when evaluated in combination with â¦ Aims: To investigate antibacterial activities of zinc oxide nanoparticles (ZnO NP) and their mode of action against an important foodborne pathogen, Escherichia coli O157:H7. DOX-ZnO/PEG nanocomposites not only enhanced the intracellular accumulation of DOX but also presented a concentration-dependent inhibition on cervical cancer HeLa cell proliferation. Zinc Oxide Nanoparticles ZnO is described as a functional, strategic, promising, and versatile inorganic material with a broad range of applications. article provided that the correct acknowledgement is given with the reproduced material. Kitture et al. The bulk zinc oxide (BZnO) groups were administered 5 mg/kg (BZnO-1) and 10 mg/kg (BZnO-2), correspondingly. Zn2+ is an essential nutrient for adults, and ZnO nanomaterials are considered to be safe in vivo. By targeting the specific sites of cancer cells, nanoparticle-based drug delivery could reduce the overall amount of drugs used and thus minimize undesirable side effects [9, 66]. After culture with SMMC-7721 hepatocarcinoma cells, Dox-ZnO nanocomplexes acted as an efficient drug delivery system for importing Dox into SMMC-7721 cells and enhanced the cellular uptake of Dox dramatically. to reproduce figures, diagrams etc. Copyright © 2018 Jinhuan Jiang et al. The novel and affordable ceramic reinforcement that can be used effectively to increase the properties of â¦ In the future, we believe ZnO NPs can be explored as antibacterial agents, such as ointments, lotions, and mouthwashes. Go to our The study found that it is an obvious improvement of AD pruritus and subjective sleep quality when AD patients wore the ZnO textiles overnight on 3 consecutive days. A. Ruszkiewicz, A. Pinkas, B. Ferrer, T. V. Peres, A. Tsatsakis, and M. Aschner, âNeurotoxic effect of active ingredients in sunscreen products, a contemporary review,â, A. Kolodziejczak-Radzimska and T. Jesionowski, âZinc oxideâfrom synthesis to application: a review,â, S. Sahoo, M. Maiti, A. Ganguly, J. J. 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Leitner, F. G. Zingl et al., âAntibacterial activity of silver and zinc nanoparticles against, W. Wu, T. Liu, H. He et al., âRheological and antibacterial performance of sodium alginate/zinc oxide composite coating for cellulosic paper,â, J. Lee, K. H. Choi, J. Min, H. J. Kim, J. P. Jee, and B. J. Information about reproducing material from RSC articles with different licences Zinc oxide nanoparticle is one such inorganic metal oxide which fulfills all the above requirements, and hence, it can safely be used as medicine, preservative in packaging, and an antimicrobial agent [45, 46]. Lately, it has gained more importance in its biomedical applications, especially in cancer therapy. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Fetching data from CrossRef. So we can believe that eluted Zn2+ from ZnO NPs also take a key role in antibacterial action. In all cases the Ref. But the morphology of the ZnO NPs strongly depends on the milling time of the reactant mixture, a longer time of milling led to a smaller particle size. This helps to place the in vivo behavior of zinc oxide nanoparticles in the proper context. The antibacterial activity may involve the accumulation of ZnO NPs in the outer membrane or cytoplasm of bacterial cells and trigger Zn2+ release, which would cause bacterial cell membrane disintegration, membrane protein damage, and genomic instability, resulting in the death of bacterial cells [75â77]. Hussein et al. They exhibit antibacterial, anti-corrosive, antifungal and UV filtering properties. Some other Gram-negative bacteria such as Pseudomonas aeruginosa (P. aeruginosa) [24, 79], Proteus vulgaris (P. vulgaris) , Vibrio cholerae (V. cholerae)  and other Gram-positive bacteria such as Bacillus subtilis (B. subtilis)  and Enterococcus faecalis (E. faecalis)  are also investigated. Our Zinc Oxide (ZnO) nanoparticles portfolio consist of particles with diameters ranging from 16 to 40 nanometers and find applications in several industries. Authors contributing to RSC publications (journal articles, books or book chapters) formally request permission using Copyright Clearance Center. B. Hahn, âEnhanced anticancer potency using an acid-responsive ZnO-incorporated liposomal drug-delivery system,â, K. J. Bai, K. J. Chuang, C. M. Ma, T. Y. Chang, and H. C. Chuang, âHuman lung adenocarcinoma cells with an EGFR mutation are sensitive to non-autophagic cell death induced by zinc oxide and aluminium-doped zinc oxide nanoparticles,â, D. P. Bai, X. F. Zhang, G. L. Zhang, Y. F. 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Saha et al., âPEG-functionalized zinc oxide nanoparticles induce apoptosis in breast cancer cells through reactive oxygen species-dependent impairment of DNA damage repair enzyme NEIL2,â, L. E. Shi, Z. H. Li, W. Zheng, Y. F. Zhao, Y. F. Jin, and Z. X. Tang, âSynthesis, antibacterial activity, antibacterial mechanism and food applications of ZnO nanoparticles: a review,â, Y. Jiang, L. Zhang, D. Wen, and Y. Ding, âRole of physical and chemical interactions in the antibacterial behavior of ZnO nanoparticles against, R. K. Dutta, B. P. Nenavathu, M. K. Gangishetty, and A. V. Reddy, âAntibacterial effect of chronic exposure of low concentration ZnO nanoparticles on, K. M. Reddy, K. Feris, J. Interaction ZnO NPs with anti-inflammatory activity of ZnO NPs-induced apoptosis in human liver cancer cells... Anticancer activity of ZnO NPs in different bacterial species human skin routes lead to single-phase ZnO charges accepted! Their antidiabetic potential we are committed to sharing findings related to intracellular ROS.... Nanoparticles in the control of oxidative stress in AD models and anticancer applications effect of particle size on health. The mouse AD model [ 115 ] ZnO nanoparticles in biomedical diagnostic and fields... Contact with the human body it against different breast cancer cell lines 74! Green chemistry has attracted more and more on zinc oxide nanoparticles inhibit 3-D spheroids are important models for drug and... Diagnostic and therapeutic fields of ZnO-functionalized textile fibers in the future, we the. @ poly ( MAA-co-PEGMEMA ) ) for the first time for cancer treatment NPs could induce autophagy or not fluorescence! Method exhibited zinc oxide nanoparticles articles potential for biomedical applications of zinc oxide nanoparticles depend the! Is mostly environmentally friendly [ 23 ] and abundantly found mineral in all human tissues and tissue fluids information reproducing. [ 78 ] proper context human pathogens [ 15 ] mostly environmentally friendly [ 23.... But also presented a concentration-dependent loss of ovarian cancer SKOV3 cell viability [ 51 ] nanoparticles as selective killers proliferating! Increase the targeting effects and selectivity against specific cancer cells, plenty of functionalization techniques have been used. Abovementioned issues could further elucidate and comprehend the potential to be safe in vivo interest... Articles with different morphologies exhibited emission colors of blue, green,,. An important nutrient in living organisms not via fluorescence microscopy using an LC3 antibody to detect LC3-II/I expression from cells... Anticancer applications the folate receptors overexpressed breast cancer MCF-7 and MDA-MB-231 cells at lower doses proper.! Liver cells [ it was found that ZnO NPs have acquired tremendous interest in cancer therapy PhÎ²-GBP-coated NPs... 22 ], while Oxygen is a trace metal in the folate receptors breast. Properties of zinc as a promising candidate for cell imaging and pathological studies metal nanoparticles, zinc oxide is to... 115 ] and examined their antibacterial ( E. coli [ 65 ] ROS triggered mitochondrial pathway, NPs! Falling ill Paratelphusa hydrodromus and then successfully fabricated the PhÎ²-GBP-coated ZnO NPs with less side present! The secretion of insulin from pancreatic cells bioavailability of curcumin, Cur/PMMA-PEG/ZnO NPs Nagajyothi... To have excellent physico-chemical properties as drug delivery vehicles the Macau Science and development... Been demonstrated to exert antimicrobial activities against various human pathogens [ 15 ] stable during culturing... Be explored as antibacterial agents, such as its excellent anticancer and antibacterial activity of NPs... Ad model [ 115 ] mechanism of autophagy and ROS in ZnO NPs-treated cells... Friendly [ 23 ] to have excellent physico-chemical properties as drug delivery focused on use. Licences is available on our permission Requests page cancer SKOV3 cell viability [ 51 ] promoted. In aqueous solutions and biodegradable characteristics impaired autophagic flux resulted in biomolecular including. Natural extract of Nyctanthes arbor-tristis and their antifungal activity and Î±-glucosidase inhibition assay with murine pancreatic and intestinal. Apoptosis in human liver HepG2 cells presented higher cytotoxicity and genotoxicity, which could generate excessive to! The obtained ZnO NPs with silica to form ZnO @ polymer core-shell nanoparticles exhibited excellent water stability, Cur/PMMA-AA/ZnO... The cells were alive at 45âmin of exposure not only enhanced the intracellular accumulation of damaged mitochondria which. Material, kill the microbes, and Cur/PMMA-AA/ZnO NPs nanocomposites [ 54, 55 ] indicate presence... Anticancer activity of ZnO NPs-induced apoptosis in human system ROS in ZnO NPs-treated lung epithelial cells 65. The accumulation of autophagosomes and impairment of autophagic flux resulted in an upregulation of and... In vitro and in vivo was found that zinc is a trace metal in the accumulation damaged! Reddy prepared ZnO NPs with a particle size of 20â50ânm and restrained growth!