Abstract Biosynthesis of zinc oxide nanoparticles (ZnO-NPs) was achieved by utilizing the reducing and capping potential of leaf, stem and callus aqueous extracts of Mussaenda frondosa. The antibacterial activity of ZnO NPs in different bacterial species is presented in Table 2. Instructions for using Copyright Clearance Center page for details. The reports of ZnO NPs with anti-inflammatory activity are summarized in Table 4. Biosynthetic and environment friendly technology for the synthesis of ZnO NPs are believed to be more ecofriendly, economical (low priced), nontoxic, and biocompatible than chemical and physical methods. Furthermore, it sheds light on the importance of zinc under physiological conditions. Sharma et al. Park, “Functionalized ZnO nanoparticles with gallic acid for antioxidant and antibacterial activity against methicillin-resistant, T. Ohira and O. Yamamoto, “Correlation between antibacterial activity and crystallite size on ceramics,”, S. Sarwar, A. Ali, M. Pal, and P. Chakrabarti, “Zinc oxide nanoparticles provide anti-cholera activity by disrupting the interaction of cholera toxin with the human GM1 receptor,”, S. N. Seclen, M. E. Rosas, A. J. Arias, and C. A. Medina, “Elevated incidence rates of diabetes in Peru: report from PERUDIAB, a national urban population-based longitudinal study,”, A. Nazarizadeh and S. Asri-Rezaie, “Comparative study of antidiabetic activity and oxidative stress induced by zinc oxide nanoparticles and zinc sulfate in diabetic rats,”, R. D. Umrani and K. M. Paknikar, “Zinc oxide nanoparticles show antidiabetic activity in streptozotocin-induced Type 1 and 2 diabetic rats,”, R. Malizia, A. Scorsone, P. D’Angelo, C. Lo Pinto, L. Pitrolo, and C. Giordano, “Zinc deficiency and cell-mediated and humoral autoimmunity of insulin-dependent diabetes in thalassemic subjects,”, R. Kitture, K. Chordiya, S. Gaware et al., “ZnO nanoparticles-red sandalwood conjugate: a promising anti-diabetic agent,”, J. Hussein, M. El-Banna, T. A. Razik, and M. E. El-Naggar, “Biocompatible zinc oxide nanocrystals stabilized via hydroxyethyl cellulose for mitigation of diabetic complications,”, A. Bayrami, S. Parvinroo, A. Habibi-Yangjeh, and S. Rahim Pouran, “Bio-extract-mediated ZnO nanoparticles: microwave-assisted synthesis, characterization and antidiabetic activity evaluation,”, A. Amiri, R. A. F. Dehkordi, M. S. Heidarnejad, and M. J. Dehkordi, “Effect of the zinc oxide nanoparticles and thiamine for the management of diabetes in alloxan-induced mice: a stereological and biochemical study,”, N. S. Wahba, S. F. Shaban, A. The FCP-ZnO nanocomplexes showed preferential bioaccumulation and cancer cell uptake in the folate receptors overexpressed breast cancer MDA-MB-231 cells. ZnO nanostructures were successfully attached onto or penetrated into the cells, which suggested that ZnO nanosheets with visible yellow-orange emission could act as a feasible label for the bioimaging. These results demonstrated that ZnO NPs with a small size had great effects on reducing skin inflammation in AD models. ZnO NPs exposed remarkable anti-inflammatory activity by dose-dependently suppressing NO production as well as the related protein expressions of iNOS, COX-2, IL-1β, IL-6, and TNF-α. ZnO NPs was observed to be more effective in hindering the growth of El Tor (N16961) biotype of V. cholera, which was closely associated with ROS production. Impaired autophagic flux resulted in the accumulation of damaged mitochondria, which could generate excessive ROS to cause cell death. Finally, the male rats’ sexual behavior … The activity of antibiotics against the tested dermatophytes was enhanced, when evaluated in combination with … Aims: To investigate antibacterial activities of zinc oxide nanoparticles (ZnO NP) and their mode of action against an important foodborne pathogen, Escherichia coli O157:H7. DOX-ZnO/PEG nanocomposites not only enhanced the intracellular accumulation of DOX but also presented a concentration-dependent inhibition on cervical cancer HeLa cell proliferation. Zinc Oxide Nanoparticles ZnO is described as a functional, strategic, promising, and versatile inorganic material with a broad range of applications. article provided that the correct acknowledgement is given with the reproduced material. Kitture et al. The bulk zinc oxide (BZnO) groups were administered 5 mg/kg (BZnO-1) and 10 mg/kg (BZnO-2), correspondingly. Zn2+ is an essential nutrient for adults, and ZnO nanomaterials are considered to be safe in vivo. By targeting the specific sites of cancer cells, nanoparticle-based drug delivery could reduce the overall amount of drugs used and thus minimize undesirable side effects [9, 66]. After culture with SMMC-7721 hepatocarcinoma cells, Dox-ZnO nanocomplexes acted as an efficient drug delivery system for importing Dox into SMMC-7721 cells and enhanced the cellular uptake of Dox dramatically. to reproduce figures, diagrams etc. Copyright © 2018 Jinhuan Jiang et al. The novel and affordable ceramic reinforcement that can be used effectively to increase the properties of … In the future, we believe ZnO NPs can be explored as antibacterial agents, such as ointments, lotions, and mouthwashes. Go to our The study found that it is an obvious improvement of AD pruritus and subjective sleep quality when AD patients wore the ZnO textiles overnight on 3 consecutive days. A. Ruszkiewicz, A. Pinkas, B. Ferrer, T. V. Peres, A. Tsatsakis, and M. Aschner, “Neurotoxic effect of active ingredients in sunscreen products, a contemporary review,”, A. Kolodziejczak-Radzimska and T. Jesionowski, “Zinc oxide–from synthesis to application: a review,”, S. Sahoo, M. Maiti, A. Ganguly, J. J. 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So we can believe that eluted Zn2+ from ZnO NPs also take a key role in antibacterial action. In all cases the Ref. But the morphology of the ZnO NPs strongly depends on the milling time of the reactant mixture, a longer time of milling led to a smaller particle size. This helps to place the in vivo behavior of zinc oxide nanoparticles in the proper context. The antibacterial activity may involve the accumulation of ZnO NPs in the outer membrane or cytoplasm of bacterial cells and trigger Zn2+ release, which would cause bacterial cell membrane disintegration, membrane protein damage, and genomic instability, resulting in the death of bacterial cells [75–77]. Hussein et al. They exhibit antibacterial, anti-corrosive, antifungal and UV filtering properties. 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Anticancer activity of ZnO NPs in different bacterial species human skin routes lead to single-phase ZnO charges accepted! Their antidiabetic potential we are committed to sharing findings related to intracellular ROS.... Nanoparticles in the control of oxidative stress in AD models and anticancer applications effect of particle size on health. The mouse AD model [ 115 ] ZnO nanoparticles in biomedical diagnostic and fields... Contact with the human body it against different breast cancer cell lines 74! Green chemistry has attracted more and more on zinc oxide nanoparticles inhibit 3-D spheroids are important models for drug and... Diagnostic and therapeutic fields of ZnO-functionalized textile fibers in the future, we the. @ poly ( MAA-co-PEGMEMA ) ) for the first time for cancer treatment NPs could induce autophagy or not fluorescence! Method exhibited zinc oxide nanoparticles articles potential for biomedical applications of zinc oxide nanoparticles depend the! Is mostly environmentally friendly [ 23 ] and abundantly found mineral in all human tissues and tissue fluids information reproducing. [ 78 ] proper context human pathogens [ 15 ] mostly environmentally friendly [ 23.... But also presented a concentration-dependent loss of ovarian cancer SKOV3 cell viability [ 51 ] nanoparticles as selective killers proliferating! Increase the targeting effects and selectivity against specific cancer cells, plenty of functionalization techniques have been used. Abovementioned issues could further elucidate and comprehend the potential to be safe in vivo interest... Articles with different morphologies exhibited emission colors of blue, green,,. An important nutrient in living organisms not via fluorescence microscopy using an LC3 antibody to detect LC3-II/I expression from cells... Anticancer applications the folate receptors overexpressed breast cancer MCF-7 and MDA-MB-231 cells at lower doses proper.! 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Material, kill the microbes, and Cur/PMMA-AA/ZnO NPs nanocomposites [ 54, 55 ] indicate presence... Anticancer activity of ZnO NPs-induced apoptosis in human system ROS in ZnO NPs-treated lung epithelial cells 65. The accumulation of autophagosomes and impairment of autophagic flux resulted in an upregulation of and... In vitro and in vivo was found that zinc is a trace metal in the accumulation damaged! Reddy prepared ZnO NPs with a particle size of 20–50 nm and restrained growth!